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https://doi.org/10.53941/ijctm.2025.100007
Yellapragada, S., & Thiagarajan, P. Intracellular Crystals in Chronic Lymphocytic Leukemia. International Journal of Clinical and Translational Medicine. 2025, 1(1), 7. doi: https://doi.org/10.53941/ijctm.2025.100007
Volume 1, Issue 1, 2025
Copyright (c) 2025 by the authors.
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This work is licensed under a Creative Commons Attribution 4.0 International License.

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Intracellular Crystals in Chronic Lymphocytic Leukemia

Sarvari Yellapragada and Perumal Thiagarajan *

Department of Pathology and Medicine, Michael E. DeBakey VA Medical Center and Baylor College of Medicine,
Houston, TX 77030, USA

* Correspondence: perumalt@bcm.edu

Received: 2 December 2024; Accepted: 9 January 2025; Published: 1 March 2025

Abstract: An 81-year-old man presented with weight loss and lymphocytosis with a white blood cell count of 55,000/µL with 80% lymphocytosis and 20% segmented neutrophils. Hemoglobin was 14 g/dL and platelets 139 × 103/µL. In flowcytometric analysis of peripheral blood, the CD19-expressing lymphocytes (52%) were positive for CD5, CD23, and CD200 and they were negative for CD10, CD103, CD25, and T-cell markers. There was no surface expression of light chains. Serum protein electrophoresis revealed mild hypogammaglobulinemia (0.60 g/dL, normal >0.69) and on immunofixation electrophoresis there was a small monoclonal spike of IgG Lambda. 

Keywords:

inclusion body immunoglobulin crystals chronic lymphatic leukemia 3

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